History and Milestones
A brief history (major milestones) of the KESM project is summarized below.
First concept: The Knife-Edge Scanning Microscope (KESM) is first conceptualized by
Bruce H. McCormick (McCormick, Neurocomputing 26-27:1025-1032 (1999)).
It was initially called the Brain Tissue Scanner (BTS).
Detailed design: The first technical report on KESM (then called the BTS) was published
by McCormick (Mccormick et al. 2002);
Patent: US patent awarded to KESM design (USPTO patent #US 6,744,572: System and method for imaging an object (2004))
Instrumentation complete: KESM is fully implemented and automation
software programming begins.
First ever full brain scans at submicrometer scale: Two whole mouse brains were imaged (Golgi and india ink). These are the very first full-brain scans at 0.6 um x 0.7 um x 1.0 um resolution. These data were reported at the Society for Neuroscience
meeting in 2009 (Choe et al. 2009). These results predate Li et al. Science, 2011 (which is largely based on KESM) by almost 3 years.
KESM Brain Atlas (first concept):
Principles underlying the KESM Brain Atlas was proposed for the first
time and a prototype is implemented. The results were reported in Eng et al. (2008).
Full-brain Golgi and India ink data published:
The two full-brain data from 2008 were presented to the public at the
Society for Neuroscience meeting Choe et al. (2009)
KESM Brain Atlas (beta) goes online: A full description of the KESMBA
and its data sets was published in Chung et al., Frontiers in Neuroinformatics, 2011.
KESMBA web site launched
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